Summary One of the largest challenges in our digital society is ensuring the security and reliability of ever-evolving software. Variability imbues every aspect of software imposing an enormous challenge for its security, optimization, and management. With the organization of the 17th International Working Conference on Variability Modelling of Software-Intensive Systems (VaMoS) we aim to allow researchers and practitioners to share ideas and results in their quest for mastering software variability, configuration, and evolution. The mixing of local experts, potential students and foreign researchers will foster sharing of knowledge and world-class research. We expect to impact emerging topics like digitalisation, cybersecurity, and sustainability of complex and highly evolving software.