Super-resolution microscopy - A key tool for dissecting synaptic architecture

Name of applicant

Ulrik Gether


University of Copenhagen


DKK 2,265,000



Type of grant

Research Infrastructure


The synapse constitutes the fundamental cellular structure enabling chemical communication between nerve cells in the brain. We propose to employ Nobel Prize winning super-resolution microscopy techniques to detailly map the molecular architecture of the presynapse for the neurotransmitter dopamine. Dopamine plays a key role in reward-based learning and is essential for our ability to move. We expect to obtain unprecedented information about the 3D-arrangement of key proteins in the presynapse and its regulation under different physiological conditions. To perform the studies, we will purchase a STORM super-resolution microscope, providing researchers at our faculty with a cutting-edge instrument enabling the study of the dynamic organization of biological structures in unmatched detail.

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