Automating cell based screening and morphological profiling

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Thomas B. Poulsen


Aarhus University


DKK 1,000,000




Research Infrastructure


To study how complex biological systems - cells and organisms - work, researchers evaluate large collections (thousands) of chemical compounds for their ability to alter the biological system. A specific example is the search for drug candidates that can stop cellular processes known to be connected to human disease. We have established a new method that allows us to investigate the full scope of biological activity connected to a given chemical compound without pre-defining the exact biological process being investigated. The new infrastructure allows us to automate the workflows involved in this experiment. This very significantly increases the experimental capacity and, as a consequence, the chances of making new biological discoveries.

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