Role of B cells in allergic contact dermatitis and in tolerance to contact allergens

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Anders Boutrup Funch


Postdoctoral Fellow


Swiss Institute of Allergy and Asthma Research


DKK 1,220,000




Internationalisation Fellowships


Allergic contact dermatitis (ACD) is a common inflammatory skin disease that affects approximately 15% of the adult European population. ACD develops when T cells are activated after exposure of the skin to a contact allergen. Due to the potential side effects of current treatments, sensitized individuals must take lifelong precautions to avoid re-exposure to allergens and prevent ACD flare-ups.


Not all develop ACD after exposure to contact allergens; instead, some develop tolerance towards the allergen through a currently unknown mechanism. However, recent research suggests that B cells may play a key role in inducing tolerance and preventing ACD. My research project will investigate the role of B cells in ACD and immune tolerance, potentially paving the way for improved ACD treatments.


The project will be done at the Swizz Institute of Allergy and Asthma Research (SIAF), Switzerland. B cells will be isolated from blood taken from 20 p-phenylenediamine (PPD)-allergic patients and 20 PPD-tolerant individuals. The phenotype and function of the B cells will be assessed by cutting-edge techniques, including single-cell RNA sequencing, proximity extension assays and 3D-skin modeling.

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