PERmeable Gut-LIver System (PERGULIS)
PERmeable Gut-LIver System (PERGULIS)
Navn på bevillingshaver
Paula de Dios Andres
Titel
Postdoctoral Fellow
Institution
ETH Zurich
Beløb
DKK 2,675,562
År
2026
Bevillingstype
Internationalisation Fellowships
Hvad?
The gut is a key organ that communicates closely with the liver, among others. When the intestinal barrier becomes compromised, harmful molecules can leak into the bloodstream and reach the liver, triggering inflammation. PERGULIS aims to develop a 3D-printed human gut tissue model that mimics the structure and function of the real organ, providing a platform for studying gut-liver communication.
Hvorfor?
Understanding how the gut and liver interact is essential because disruptions in this communication are linked to many diseases, including metabolic and inflammatory disorders. Current laboratory models cannot fully reproduce human gut physiology. PERGULIS will provide a more realistic system to study the communication between the gut and liver.
Hvordan?
Using advanced 3D bioprinting, hollow gut-like structures will be fabricated from biomaterials and populated with human cells. These engineered tissues will mimic natural gut movements and barrier functions. By inducing a permeable state, I will study how substances cross the gut barrier and influence liver responses.